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NEXTSTELLIS, the first and only oral contraceptive pill containing E4, has been approved by the U.S. Food and Drug Administration (FDA). E4 is a naturally occurring estrogen that is now being produced from a plant source, and differs from other estrogens as a Native Estrogen with Selective actions in Tissues (NEST). Mitchell Creinin, Professor and Director of Family Planning at the University of California, Davis, stated, “When speaking with patients about their contraceptive options, one of the most common concerns is side effects. NEXTSTELLIS is an innovative contraceptive that has been shown to be not only safe and effective, but also well tolerated in clinical trials with a desirable bleeding profile and minimal impact on triglycerides, cholesterol, and glucose, as well as weight and endocrine markers.”

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