European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has announced their approval of diroximel fumarate (Vumerity, Biogen Inc) for adults diagnosed with relapsing-remitting multiple sclerosis (MS). Although Diroximel fumarate is comparable to dimethyl fumarate (Tecfidera, Biogen Inc) in effectiveness, the drug does have a unique chemical structure that less likely to induce strong irritation in the gastrointestinal (GI) tract, as shown in the EVOLVE-MS-2 clinical trial. The backing will now be reviewed by the European Commission. Diroximel fumarate has already been approved by the US FDA (Food and Drug Administration) for MS.
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