{"id":175949,"date":"2022-03-03T13:27:03","date_gmt":"2022-03-03T20:27:03","guid":{"rendered":"https:\/\/lifesciences.csoftintl.com\/?p=175949"},"modified":"2022-03-11T02:40:45","modified_gmt":"2022-03-11T09:40:45","slug":"fda%e6%8c%87%e5%ae%9a%e6%8e%88%e4%ba%88i-mab%e5%85%ac%e5%8f%b8%e7%9a%84tj-cd4b%e5%ad%a4%e5%84%bf%e8%8d%af%e7%a7%b0%e5%8f%b7","status":"publish","type":"post","link":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/blog\/fda%e6%8c%87%e5%ae%9a%e6%8e%88%e4%ba%88i-mab%e5%85%ac%e5%8f%b8%e7%9a%84tj-cd4b%e5%ad%a4%e5%84%bf%e8%8d%af%e7%a7%b0%e5%8f%b7\/","title":{"rendered":"FDA\u6307\u5b9a\u6388\u4e88I-Mab\u516c\u53f8\u7684TJ-CD4B&#8221;\u5b64\u513f\u836f\u201c\u79f0\u53f7"},"content":{"rendered":"<p>I-Mab\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(FDA)\u5df2\u6388\u4e88\u5176\u65b0\u578bClaudin 18.2 x 4-1BB\u53cc\u7279\u5f02\u6027\u6297\u4f53TJ-CD4B &#8220;\u5b64\u513f\u836f &#8220;\u79f0\u53f7\uff0c\u7528\u4e8e\u6cbb\u7597\u80c3\u764c\uff0c\u5305\u62ec\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u7684\u764c\u75c7\u3002TJ-CD4B\u662f\u7b2c\u4e00\u4e2a\u4e34\u5e8a\u9636\u6bb5\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u5b83\u4e0e\u8868\u8fbeClaudin 18.2\uff08CLDN18.2\uff09\u7684\u764c\u7ec6\u80de\u548cT\u7ec6\u80de\u4e0a\u7684\u5171\u523a\u6fc0\u5206\u5b504-1BB\u7ed3\u5408\uff0c\u53d1\u6325\u6740\u4f24\u80bf\u7624\u7684\u4f5c\u7528\u3002\u7531\u4e8e\u5b83\u6db5\u76d6\u4e86\u8868\u8fbe\u4f4e\u6c34\u5e73CLDN18.2\u7684\u764c\u75c7\uff0cTJ-CD4B\u7684\u6297\u80bf\u7624\u6548\u679c\u6bd4\u5176\u4ed6\u6d89\u53caCLDN18.2\u7684\u7597\u6cd5\u66f4\u5e7f\u6cdb\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8fd8\u63d0\u51faTJ-CD4B\u6bd4\u76ee\u524d\u7684CLDN18.2\u6297\u4f53\u548c4-1BB\u6fc0\u52a8\u5242\u6297\u4f53\u66f4\u6709\u4f18\u52bf\uff0c\u56e0\u4e3a\u5b83\u5177\u6709\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u6700\u5c0f\u76844-1BB\u76f8\u5173\u7684\u7cfb\u7edf\u6027\u6bd2\u6027\u3002\u80c3\u764c\u5360\u7f8e\u56fd\u6240\u6709\u65b0\u8bca\u65ad\u764c\u75c7\u76841.5%\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u662f\u7b2c\u4e94\u5927\u6700\u5e38\u89c1\u7684\u764c\u75c7\uff0c\u4e5f\u662f\u764c\u75c7\u5bfc\u81f4\u6b7b\u4ea1\u7684\u7b2c\u4e09\u5927\u539f\u56e0\u3002I-Mab\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u65b0\u578b\u751f\u7269\u5236\u5242\uff0c\u4ee5\u6cbb\u7597\u5177\u6709\u91cd\u5927\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u75be\u75c5\uff0c\u7279\u522b\u662f\u764c\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002<\/p>\n<p>\u9605\u8bfb<a href=\"https:\/\/www.biospace.com\/article\/releases\/i-mab-receives-fda-orphan-drug-designation-for-its-novel-claudin-18-2-x-4-1bb-bispecific-antibody-tj-cd4b-for-the-treatment-of-gastric-cancer\/\">\u66f4\u591a<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>I-Mab\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(FDA)\u5df2\u6388\u4e88\u5176\u65b0\u578bClaudin 18.2 x 4-1BB\u53cc\u7279\u5f02 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":175282,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false},"categories":[953,467,754],"tags":[752,1379,1454,1460],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/posts\/175949"}],"collection":[{"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=175949"}],"version-history":[{"count":2,"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/posts\/175949\/revisions"}],"predecessor-version":[{"id":175951,"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/posts\/175949\/revisions\/175951"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/media\/175282"}],"wp:attachment":[{"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=175949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=175949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifesciences.csoftintl.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=175949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}